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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Eur J Immunol. 2013 Oct 20;44(1):239–250. doi: 10.1002/eji.201343774

Figure 5. Two-stage kinetics of TCR-CD8 dual-receptor interaction with pMHC.

Figure 5

Adhesion frequencies (Pa) were measured for hybridomas interacting with RBCs coupled with gp209-2M:HLA-A2 in a range of contact times. Normalized adhesion bonds (<n>/mpMHC), calculated from <n> = − ln(1 − Pa) divided by the pMHC site density mpMHC (Eq. 2, Supporting Information Materials and Methods), were plotted vs. contact time for different TCRs (A–F). Error bars represent uncertainty based on error propagation from adhesion frequency measurements.