Table 2.
Markers with highest sensitivity / specificity for the identification of CE stroke.
| Marker | Sample Size | Cutoff Point | Sensitivity | Specificity | PPV | NPV | Ref |
|---|---|---|---|---|---|---|---|
| BNP | 707 | >76 pg/mL | 68% | 72% | 55% | 82% | [24] |
| D-dimer | 707 | >300 ug/L | 100% | 52% | 46% | 73% | [24] |
| BNP combined with D-dimer | 707 | - | 66.5% | 91.3% | - | - | [24] |
| Pro-BNP | 262 | >360 pg/mL | 87% | 83% | - | - | [32] |
| ANP | 262 | >2266.6 fmol/mL | 62% | 70% | - | - | [32] |
| NT-proBNP | 92 | >265 pg/mL | 71.4% | 73.7% | 77.8% | 66.6% | [27] |
| CK-MB | 89 | >1.5 ng/mL | 47.9% | 85% | 79.3% | 79.3% | [39] |
| BNP combined with CK-MB | 89 | - | 31.2% | 95% | 88.2% | 53.5% | [39] |
ANP: atrial natriuretic peptide; BNP: b-type natriuretic peptide; CK-MB: creatine kinase MB; NT-proBNP: N-terminal part of pro-BNP; NPV: Negative predictive value; PPV: Positive predictive value