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Distribution of downstream (A) and upstream (B) nucleotides for editing sites detected in the HBM data sets. Edited sites are split into three groups according to their editing level: low level ≤10%, high level ≥40%, and medium level >10% and <40%. A clear signature of the ADAR sequence preference is observed (low G upstream of the site, and some enrichment downstream from the site). The preference is stronger at sites with high editing levels.
