Table 2.
Biochemical and hormonal parameters in 17 male patients with 21-OHD at study start (baseline) and after 2-year follow-up.
| Baseline | Follow-up | |
|---|---|---|
| BMI (kg/m2) | 26.2 ± 5.5 (16.5–38) | 25.5 ± 5.6 (19–38.5) |
| BP systolic/diastolic (mmHg) | 118/78 ± 12/8 (100–135/60–90) |
117/73* ± 17/10 (90–145/60–90) |
| Potassium (mmol/L) | 3.76 ± 0.43 (3.2–4.7) | 3.92 ± 0.34 (3.4–4.6) |
| Sodium (mmol/L) | 140.8 ± 1.8 (136–144) | 139.5 ± 2.7 (134–143) |
| Cholesterol (mg/dL) | 169 ± 36 (126–237) | 185 ± 43 (106–247) |
| Triglycerides (mg/dL) | 103 ± 57 (44–219) | 116 ± 62 (48–256) |
| ACTH (pg/mL) | 153 ± 331 (5–1250) | 62 ± 141 (5–561) |
| 17-OHP (ng/mL) | 14.9 ± 18.8 (0.8–50) | 25.2 ± 58.8 (0.8–218) |
| Androstenedione (ng/mL) | 1.55 ± 2.39 (0.2–10) | 1.85 ± 3.15 (0.2–10.4) |
| DHEAS (ng/mL) | 620 ± 778 (90–3395) | 442 ± 378 (1–1246) |
| Testosterone (ng/mL) | 5.0 ± 2.6 (1.7–9.6) | 4.4 ± 2.6 (1.5–9.5) |
| SHBG (nmol/L) | 41 ± 20 (14–77) | 44 ± 25 (12–99) |
| Free testosterone index | 46.3 ± 20.5 (15.4–100.6) | 40.1 ± 24.4 (7.3–113.8) |
| AD/T ratio | 0.41 ± 0.57 (0.06–1.96) | 0.45 ± 0.81 (0.06–3.26) |
| Estradiol (pg/mL) | 26.6 ± 8.0 (15.6–41.1) | 21.8 ± 12.2 (5.0–49.5) |
| Renin (ng/L)§ | 84.3 ± 130.7 (2.5–330) | 288.7 ± 767.7 (2.5–2592) |
| LH basal (U/L) | 4.1 ± 2.2 (1.5–8.9) | 3.8 ± 2.9 (0.6–7.9) |
| LH peak (U/L) | 31.9 ± 12.3 (13.5–61.3) | 25.7 ± 16.8 (0.8–53.4) |
| Δmax LH | 27.8 ± 11.1 (7.9–53.6) | 22.0 ± 15.5 (0.3–46.2) |
| FSH basal (U/L) | 7.1 ± 6.8 (2.3–28.9) | 6.1 ± 4.0 (1.9–12.9) |
| FSH peak (U/L) | 12.9 ± 11.1 (4.4–46) | 9.5 ± 8.5 (1.0–26.2) |
| Δmax FSH | 5.9 ± 4.8 (0.6–17.1) | 4.3 ± 4.5 (1.0–13.3) |
| Daily GC equivalent dose/m2
BSA (mg/m2) |
19.8 ± 5.8 (10.0–33.3) | 18.6 ± 6.9 (9.2–30.6) |
Data are means ± SD (range). BMI: body mass index; BP: blood pressure; BSA: body surface area. Normal ranges (SI units shown in brackets): sodium 134–145 mmol/L; potassium 3.4–5.2 mmol/L; cholesterol < 200 mg/dL (5.17 mmol/L); triglycerides < 180 mg/dL (2.06 mmol/L). Conversion factors: androstenedione (AD) X3.49 nmol/liter; testosterone (T) X3.47 nmol/liter; 17-hydroxy-progesterone (17OHP) X3.026 nmol/liter; estradiol X3.67 pmol/liter; and DHEAS X2.57 nmol/liter. Δmax denotes the differences between peak and basal LH or FSH concentration. The dose of daily glucocorticoid was converted into milligrams of daily hydrocortisone equivalent (1 mg dexamethasone = 14 mg prednisolone = 70 mg hydrocortisone). Free testosterone index (fTI) was calculated by the ratio 347 ∗ testosterone (ng/mL)/SHBG (nmol/L) [31]. §Renin was measured only in SW CAH patients. *P < 0.05 versus baseline.