Table 3.
Biochemical and hormonal parameters in male patients with 21-OHD depending on AD/T ratio at study start (baseline).
| AD/T ratio <0.2 | AD/T ratio >0.2 | |
|---|---|---|
| BMI (kg/m2) | 25.4 ± 5.9 | 27.8 ± 4.8 |
| BP systolic/diastolic (mmHg) | 120/79 ± 14/7 | 119/79 ± 6/6 |
| Potassium (mmol/L) | 3.81 ± 0.36 | 3.68 ± 0.55 |
| Sodium (mmol/L) | 141.2 ± 0.9 | 140.0 ± 2.8 |
| Cholesterol (mg/dL) | 178 ± 40 | 154 ± 22 |
| Triglycerides (mg/dL) | 106 ± 68 | 100 ± 44 |
| 17-OHP (ng/mL) | 2.7 ± 2.5 | 35.2 ± 16.1*** |
| Androstenedione (ng/mL) | 0.52 ± 0.27 | 3.28 ± 3.36* |
| DHEAS (ng/mL) | 425 ± 239 | 944 ± 1228 |
| Testosterone (ng/mL) | 5.7 ± 2.6 | 4.0 ± 2.4 |
| Free testosterone index | 47.0 ± 12.5 | 33.1 ± 17.4 |
| AD/T ratio | 0.09 ± 0.03 | 0.94 ± 0.68*** |
| Estradiol (pg/mL) | 25.5 ± 8.3 | 28.2 ± 3.4 |
| LH basal (U/L) | 4.4 ± 2.4 | 3.6 ± 1.9 |
| Δmax LH | 31.5 ± 10.1 | 18.5 ± 8.1* |
| FSH basal (U/L) | 8.1 ± 7.9 | 4.5 ± 1.3 |
| Δmax FSH | 7.1 ± 5.1 | 2.8 ± 1.9 |
| No. of adrenal crisis during 2-year follow-up | 2 | 1 |
| % of patients with TART | 18% | 17% |
| daily GC equivalent dose/m2
BSA (mg/m2) |
20.5 ± 5.7 | 18.7 ± 6.2 |
| % of patients receiving any treatment regimen with dexamethasone | 55% | 0%* |
| % SW | 64% | 67% |
| Daily fludrocortisone dose/m2
BSA (mg/m2), § |
60.1 ± 15.4 | 53.5 ± 7.1 |
Data are means ± SD. BMI: body mass index; BP: blood pressure; BSA: body surface area. Normal ranges (SI units shown in brackets): sodium 134–145 mmol/L; potassium 3.4–5.2 mmol/L; cholesterol < 200 mg/dL (5.17 mmol/L); triglycerides < 180 mg/dL (2.06 mmol/L). Conversion factors: androstenedione (AD) X3.49 nmol/liter; testosterone (T) X3.47 nmol/liter; 17-hydroxy-progesterone (17OHP) X3.026 nmol/liter; estradiol X3.67 pmol/liter; and DHEAS X2.57 nmol/liter. Δmax denotes the differences between peak and basal LH or FSH concentration. The dose of daily glucocorticoid was converted into milligrams of daily hydrocortisone equivalent (1 mg dexamethasone = 14 mg prednisolone = 70 mg hydrocortisone). Free testosterone index (fTI) was calculated by the ratio 347 ∗ testosterone (ng/mL)/SHBG (nmol/L) [31]. §Only in SW CAH patients. *P < 0.05; ***P < 0.001.