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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Dec 5;34(2):279–284. doi: 10.1161/ATVBAHA.113.302781

Figure 4. LXR activation decreases atherosclerosis in Ldlr−/− mice transplanted with BM deficient in macrophage Abca1 and Abcg1.

Figure 4

Figure 4

Ldlr−/− mice were transplanted with Abca1fl/flAbcg1fl/fl or LysmCreAbca1fl/flAbcg1fl/fl BM and fed WTD with or without GW supplementation for 12 weeks. A. Atherosclerotic lesion area in the aortic root. Each datapoint represents a single mouse. B. Lesion severity expressed as number of observations. Differences of distribution of lesions between groups are indicated. C. MCP-1 plasma levels. n=11–13 mice per group. *P< 0.05, **P<0.01, ***P<0.001.