Table 1.

Facts on DNA replication dynamics

	T4	T7	E. coli	Archaea	S. cerevisiae	Human
Length of Okazaki fragment (kb)a	1.5–2.2	2.3	1.5	0.09–0.16	0.16b	0.1–0.2c
Primer length (nt)d	4–5	4–5	10–12	∼10	8–10	11–14
SSB/RPA binding (nt)e,f	10	14	32 or 64	4.5–5	19 or 27	8 or 30
Rate of fork progression (bp sec−1)g	600	370	600–1000	88–330	26–48	25
Replicon size (kb)h	40	166	4600	1000, 700, 500	36	∼100

^aEdenberg and Huberman 1975; Kornberg and Baker 1992; Debyser et al. 1994; Chastain et al. 2000; Matsunaga et al. 2003; Smith and Whitehouse 2012.

^bOkazaki fragment length matches that of nucleosome binding in yeast. Multiples of 165 nt, 330 nt, and 495 nt were reported.

^ccExtrapolation from the study of SV40 system.

^ddFrick and Richardson 2001; Matsunaga et al. 2003.

^eeKim et al. 1992; Kornberg and Baker 1992; Blackwell and Borowiec 1994; Kumaran et al. 2006.

^ffExtent of binding by a functional unit; T4 gp32 is a monomer, T7 gp2.5 is a homodimer, bacterial SSB is a homotetramer, archaeal SSB is a monomer, and the eukaryotic RPAs are heterotrimers.

^ggEdenberg and Huberman 1975; Rabkin and Richardson 1990; Kornberg and Baker 1992; Myllykallio et al. 2000; Raghuraman et al. 2001; Kerr et al. 2003; Duggin et al. 2008.

^hhEdenberg and Huberman 1975; Kornberg and Baker 1992; Duggin et al. 2008; Liachko et al. 2010.