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Change in IFN-γ level (antigen-stimulated value − unstimulated value) before and after IPT or OBS. IFN-γ concentrations from each subject are shown (♦). Median levels are indicated by the heavy lines. The QuantiFERON-TB Gold In-Tube diagnostic cutoff level for a positive test is shown by the dashed lines at 0.35 IU/mL. IFN-γ = interferon-γ; IPT = isoniazid preventive therapy; OBS = observation.
