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. 2013 Apr 18;1(1):1–8. doi: 10.1093/gastro/got013

Table 1.

Management of PPG.

Topical management

  1. Daily wound care.

  2. Moisture-retentive dressings.

  3. Topical agents, such as steroids or tacrolimus 0.3% preparations. Empiril antibiotic treatment can be applied if infection is suspected.

  4. Intralesional injection of triamcinolone hexacetonide or cyclosporine.

  5. Avoid ulcer debridement.

Systemic management
Disease control

  1. Prednisone, 1 mg/kg per day.

  2. Hydrocortisone, 100 mg four times daily, intravenous injection.

  3. Methylprednisolone, 1 g/day (pulse therapy), intravenous injection.

Maintenance therapy

  1. Dapsone, 100–300 mg per day.

  2. Minocycline, 100 mg twice daily.

  3. Cyclosporin, 3–5 mg/kg per day.

  4. Others: tacrolimus, 6-mercaptopurine, cyclophosphamide and chlorambucil

Others

  1. Biologics: infliximab, adalimumab and etanercept.

  2. Plasma exchange.

  3. Human immunoglobulin infusion.

  4. Interferon-a therapy.

General management

  1. Stoma care.

  2. Pain relief.

  3. Correction of anemia and malnutrition.