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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: Nat Immunol. 2012 Jun 24;13(8):753–760. doi: 10.1038/ni.2360

Figure 4.

Figure 4

Impaired microglia development in IL-34-deficient mice. (a) Total CD45intCD11b+ microglial cells in the brains of wild-type and Il34LacZ/LacZ mice (n = 4 per group). Each symbol represents an individual mouse; small horizontal lines indicate the mean. *P = 0.0004 (unpaired Student’s t-test). (b–f) Immunohistochemistry of wild-type and Il34LacZ/LacZ mouse cerebral cortex (b), corpus callosum (c), hippocampus (d), striatum (e) and cerebellum (f) in fixed brain tissues stained with the myeloid marker IBA-1. Original magnification, ×200 (scale bars, 100 μm). Data are representative of three experiments (a) or represent two independent experiments (b–f).