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. 2014 Mar 4;6:3. doi: 10.3389/fnsyn.2014.00003

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Copyright © 2014 Krieg and Triesch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity-dependent metaplasticity in accordance with the BCM theory. The experimental data (Wang and Wagner, 1999) in the control conditions (filled squares) reveal slight LTD at low conditioning frequency (<5 Hz) and strong LTP above. After priming the postsynaptic cell with a 100 Hz stimulus (empty squares) the LTD window becomes larger (up to 30 Hz) and stronger (amplitude doubles). In the model the control case (filled circles) corresponds to an average postsynaptic activity history of 10 Hz, while in the priming case (empty circles) the neuron was stimulated with 100 Hz for 3 s before the conditioning. Upon priming the model displays the same leftward shift of LTD/LTP crossover point and an increase in LTD amplitude.