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. 2014 Mar 4;6:3. doi: 10.3389/fnsyn.2014.00003

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Copyright © 2014 Krieg and Triesch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasticity depends on postsynaptic depolarization. Simulation of a distal synapse (700 μm from soma) with only NMDA receptors. Pairing presynaptic spikes with postsynaptic voltage clamping at the soma leads to no change for slight depolarization, LTD for intermediate and LTP for strong depolarization (solid line). We scaled the parameter σ linearly with the initial synaptic strength for the depressed and potentiated synapses (see Text). Depressed synapses (dashed line) have a smaller LTD window and potentiated synapses (dotted line) a larger one.