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HG concentrations and Akt expression in HMEC-1 s. (A) In a time dependent manner, decreased Akt phosphorylation but no changes in MAP kinase were shown 0.5 to 12 hours after HG (40 mM D-glucose) treatment. (B) Down-regulation of Akt phosphorylation was noted after HG treatment with a dose dependent manner, whereas no change was observed for MAP kinase phosphorylation.
