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. 2014 Feb 26;13:53. doi: 10.1186/1475-2840-13-53

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Copyright © 2014 Lee et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Axl modulates expression of angiogenic factors in HG-induced angiogenesis. The results revealed that the Axl overexpression in HMEC-1 s significantly reversed HG-induced VEGF and VEGFR2 expression (A and B). The Axl-shRNA-infected HMEC-1 cells showed significant additively decreased changes in the HG (40 mM)-induced VEGF and VEGFR2 expression (C and D).