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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: J Alzheimers Dis. 2014;39(1):145–162. doi: 10.3233/JAD-131238

Fig. 1.

Fig. 1

Effects of high fat (HF) feeding on glucose tolerance test in SAMP8, SAMPR1, and C57BL/6J mice before beginning HF diet (Zero Time), and after 8/12 weeks of HF feeding, performed after overnight fasting at every 20 min up to 2 h post a single bolus glucose injection (2 mg/kg). Glucose tolerance test at Zero Time shows peaking of blood glucose levels between 20–30 min and quickly normalizing thereafter, suggestive of normal functioning of pancreas. On the other hand, glucose tolerance test after 8/12 weeks of HF diet showed that peaking of blood glucose levels for SAMP8 and SAMPR1 mice, but not for c57BL/6J mice, at 20–30 min, consistently maintained high up to 90 min with a gradual decline by 120 min, indicating failure of pancreas and development of type 2 diabetes, as opposed to normal functioning of pancreas in C57BL/6J mice.