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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: J Alzheimers Dis. 2014;39(1):145–162. doi: 10.3233/JAD-131238

Fig. 2.

Fig. 2

Effect of high fat (HF) diet induced experimental T2DM on Morris water maze acquisition learning in SAMP8 and SAMPR1 mice, as measured by latency (Time in seconds required to reach the submerged platform). Data are presented as group means ± standard deviation (SD) derived from the average individual values (6 trials/animal/day for 3 days) for each group. Note that compared to low-fat (LF) fed non-diabetic SAMPR1 mice, spatial acquisition learning was observed to be gradually worsened from HF-fed diabetic SAMPR1 mice (1.4-fold) > LF-fed non-diabetic SAMP8 mice (1.6-fold) > HF-fed diabetic SAMP8 mice (2.4-fold). Data indicate the most significantly deteriorated spatial acquisition learning in diabetic SAMP8 mice.