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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: J Alzheimers Dis. 2014;39(1):145–162. doi: 10.3233/JAD-131238

Fig. 7.

Fig. 7

Effect of high fat diet induced experimental T2DM on the immunoreactivities (IR) of Aβ (4G8) and phospho-tau (AT8) in the CA1-3 and dentate gyrus (DG) hippocampal subfields of SAMPR1 and SAMP8 mice. Data are represented as group mean ± standard deviation (SD) derived from average individual values for each group. Note that both high fat fed diabetic SAMPR1 mice and low fat fed non-diabetic SAMP8 mice showed more or less similar pattern of 4G8-IR Aβ and AT8-IR phospho-tau within Ca1-3 and DG, which were 1.8–2.0-fold higher for 4G8-IR and 2.5–2.6-fold higher for AT8-IR than the low fat fed non-diabetic SAMPR1 mice. Feeding of high fat diet to SAMP8 mice resulted in 1.7–2.2-fold increase in 4G8-IR Aβ and 1.4–1.5-fold increase in AT8-IR phospho-tau within the respective hippocampal subfields. Data indicate that diabetic SAMP8 mice exhibited Alzheimer-like changes with regard to Aβ and phospho-tau.