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Hypothetical model for BNF-induced cell cycle arrest and senescence. BNF induces MCF-7 cells accumulation in G0/G1 phase of the cell cycle and cell senescence by activating AhR. BNF reduces cyclinD1/D4 and CDK4 through inhibiting PI3K/AKT pathway, and increases p21Cip1/Waf1 through activating MAPK/ERK signaling in the presence of ERα. Meanwhile, BNF also causes ERα degradation through ubiquitination-proteasome pathway.
