Table I.

Interactions between rs2562796 and rs16832404, and the effect on lung cancer risk

Study	Single-locus association analysis				Interaction
	rs2562796 G/Ta		rs16832404 A/Ga		rs2562796-rs16832404
	OR (95% CI)b	P b	OR (95% CI)b	P b	OR (95% CI)b	P b
GWAS	1.03 (0.95–1.12)	4.94×10−1	1.06 (0.97–1.17)	2.12×10−1	2.58 (2.24–2.97)	1.37×10−39
Replication I	1.00 (0.90–1.12)	9.66×10−1	1.08 (0.96–1.21)	1.98×10−1	1.17 (0.99–1.38)	6.37×10−2
Replication II	1.05 (0.97–1.14)	2.13×10−1	1.01 (0.92–1.10)	8.67×10−1	1.21 (1.06–1.38)	4.61×10−3
Combined	1.05 (1.00–1.10)	5.62×10−2	1.05 (0.99–1.11)	9.53×10−2	1.33 (1.23–1.43)	1.03×10−13

^aMajor/minor alleles.

^bAdjusted for age, gender, pack-years of smoking and eigenvectors where appropriate.