Table I.
Study | Single-locus association analysis | Interaction | ||||
---|---|---|---|---|---|---|
rs2562796 G/Ta | rs16832404 A/Ga | rs2562796-rs16832404 | ||||
OR (95% CI)b | P b | OR (95% CI)b | P b | OR (95% CI)b | P b | |
GWAS | 1.03 (0.95–1.12) | 4.94×10−1 | 1.06 (0.97–1.17) | 2.12×10−1 | 2.58 (2.24–2.97) | 1.37×10−39 |
Replication I | 1.00 (0.90–1.12) | 9.66×10−1 | 1.08 (0.96–1.21) | 1.98×10−1 | 1.17 (0.99–1.38) | 6.37×10−2 |
Replication II | 1.05 (0.97–1.14) | 2.13×10−1 | 1.01 (0.92–1.10) | 8.67×10−1 | 1.21 (1.06–1.38) | 4.61×10−3 |
Combined | 1.05 (1.00–1.10) | 5.62×10−2 | 1.05 (0.99–1.11) | 9.53×10−2 | 1.33 (1.23–1.43) | 1.03×10−13 |
aMajor/minor alleles.
bAdjusted for age, gender, pack-years of smoking and eigenvectors where appropriate.