Table 2.
Clinical and biochemical characteristics of 209 subjects with NAFLD divided by serum cytokeratin-18 tertiles.
| Cytokeratin-18 tertiles | P | |||
|---|---|---|---|---|
| I | II | III | ||
| Males (%) | 68.1 | 63.0 | 62.7 | ns |
| Age (yrs) | 53.8 ± 12.9 | 54.7 ± 10.9 | 54.2 ± 12.3 | ns |
| Body mass index (kg/m2) | 27.2 ± 3.9 | 31.6 ± 3.3 | 36.1 ± 5.4 | <0.001 |
| Urinary 8-iso-PGF2α (pg/mg creatinine) | 616.7 ± 122.9 | 727.5 ± 82.1 | 800.9 ± 82.1 | <0.001 |
| HOMA-IR | 2.8 (1.9/4.0) | 3.2 (2.4/5.7) | 5.3 (3.4/7.3) | <0.001 |
| Total cholesterol (mg/dL) | 201.4 ± 38.4 | 196.9 ± 38.5 | 201.4 ± 41.5 | ns |
| HDL (mg/dL) | 50 (43/61) | 47 (38/54) | 43 (39/51) | <0.05 |
| Triglycerides (mg/dL) | 125.5 (85.5/160.3) | 138 (102.0/180.5) | 165.0 (125.0/206.0) | <0.01 |
| γ-GT (IU/L) | 23 (16.8/36.5) | 27 (17.5/44.0) | 30 (18/53) | ns |
| ALT (IU/L) | 31 (22.8/40) | 28 (20/41.5) | 26 (20/40) | ns |
| AST (IU/L) | 22 (18/28) | 21 (17/26.5) | 21 (17/28) | ns |
| Adiponectin (ng/mL) | 12 (10.4/14.1) | 7.5 (5.5/10.5) | 5 (4/7) | <0.001 |
| sNOX2-dp (pg/mL) | 49 (40/58.3) | 60 (50/66) | 67 (64/71) | <0.001 |
| Hamaguchi score | 3.5 ± 1.3 | 4.0 ± 1.3 | 4.3 ± 1.3 | <0.01 |
| Metabolic syndrome (%) | 49.4 | 69.0 | 84.8 | <0.001 |
| Diabetes (%) | 20.3 | 30.1 | 43.3 | <0.05 |