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. 2013 Jul 8;4(4):439–452. doi: 10.3945/an.113.003798

Figure 2.

Figure 2

Location and associated effects of PPAR-α variants. Environmental factors such as diet and drugs may interact with PPARα genetic variants to modulate metabolic parameters. The L162V single nucleotide polymorphism (SNP) in the PPARα coding region has been associated with an increase in TG, total cholesterol (TC), LDL, ApoB, ApoC3, the risk of type 2 diabetes (T2D), and a decrease in HDL. There is an interaction between the SNP V227A or L162V with PUFA intake that is associated with a decrease in the levels of HDL, ApoA1, TGs, and ApoC3. In addition, the intron 7 G > C variant is associated with the fenofibrate response, dyslipidemia and risk of nonfatal myocardial infarction. The domains represented in the figure are activation function-1 (AF-1), DNA binding domain (DBD), and ligand binding domain (LBD). LDL-C, low density lipoprotein-cholesterol.