Table 2. Comparison of various release characteristics of theophylline from different type of polymers in microparticles formulations, and theophylline SR® Tablet.
| Formulation | codeQ 2 a, % | Q 8 b, % | DE c | T d 50%, h | f1 e |
|---|---|---|---|---|---|
| FEC | 25 ± 2.10 | 91.87 ± 3.40 | 80.48 ± 4.21 | 4 | 32.59 ± 2.23 |
| FRS | 22.24 ± 1.16 | 68.27 ± 1.22 | 67.8 ± 3.55 | 3.5 | 67.91 ± 4.42 |
| FCAB | 6.45 ± 0.16 | 71.39 ± 2.06 | 69.39 ± 4.01 | 5 | 19.91 ± 1.23 |
| FRL | 7.41 ± 0.03 | 77.97 ± 1.17 | 72.36 ± 5.52 | > 3 | 30.44 ± 3.67 |
| Theophylline SR® | 12.89 ± 1.55 | 80.86 ± 5.73 | 73.72 ± 3.98 | 4 | 0 |
aAmount of drug release after 2h
bAmount of drug release after 8h
cDissolution Efficiency
dDissolution time for 50% fractions
eDifference factor