Table 3. Fitting parameters of the in vitro release data to various release kinetics models.
FEC | FRS | FCAB | FRL | Theophylline SR | |
---|---|---|---|---|---|
Zero f=kt | |||||
K | 0.0006 | 0.0008 | 0.0428 | 0.0005 | 0.0007 |
RSQ | 0.5148 | 0.9114 | 0.8421 | 0.3848 | 0.6869 |
D(SS), % | 723.1258 | 701.1646 | 426.1421 | 712.4172 | 459.3552 |
First Ln(1-f)=k | |||||
K | 0.0022 | 0.0031 | 0.3844 | 0.0014 | 0.0032 |
RSQ | 0.7205 | 0.8517 | 0.9452 | 0.5976 | 0.9936 |
D(SS), % | 309.546 | 373.0134 | 2419.9759 | 525.5641 | 745.9072 |
Peppas Lnf=lnk+blnt |
|||||
b | 0.34091 | 0.2076 | 0.8920 | 0.7511 | 1.2330 |
K | 0.0518 | 0.1894 | 0.0802 | 0.0045 | 0.0004 |
RSQ | 0.9433 | 0.8757 | 0.8166 | 0.5780 | 0.9725 |
D(SS), % | 22.4856 | 23.9331 | 327.5811 | 270.5196 | 97.9302 |
Higuchi f=kt 0.5 | |||||
K | 0.0295 | 0.0381 | 0.2465 | 0.0218 | 0.0339 |
RSQ | 0.7260 | 0.9344 | 0.9478 | 0.7096 | 0.8721 |
D(SS), % | 201.3116 | 225.0460 | 1753.5811 | 950.3229 | 1398.717 |