Table 1.
Proteins Upregulated by Traumatic Brain Injury
| IPA name | Ratio | Accession no. | Uniprot name | Protein name |
|---|---|---|---|---|
| Actin-related | ||||
| CAPG | 4.01 | Q6AYC4 | CAPG | Macrophage-capping protein |
| HLA-C | 3.49 | P16391 | HA12 | RT1 class I histocompatibility antigen; AA alpha chain precursor |
| TPM4 | 3.23 | P09495 | TPM4 | Tropomyosin alpha-4 chain |
| HSPB1 | 2.27 | P42930 | HSPB1 | Heat shock protein beta-1 |
| EVL | 2.08 | O08719 | EVL | Ena/VASP-like protein |
| CNN3 | 1.73 | P37397 | CNN3 | Calponin-3 |
| MARCKS | 1.73 | P30009 | MARCS | Myristoylated alanine-rich C-kinase substrate |
| SEPT5 | 1.51 | Q9JJM9 | SEPT5 | Septin-5 |
| PPP1R9A | 1.42 | O35867 | NEB1 | Neurabin-1 |
| PPP1R9B | 1.40 | O35274 | NEB2 | Neurabin-2 |
| MYH9 | 1.37 | Q62812 | MYH9 | Myosin-9 |
| ACTN4 | 1.26 | Q9QXQ0 | ACTN4 | Alpha-actinin-4 |
| ACTA2 | 1.26 | P62738 | ACTA | Actin; aortic smooth muscle |
| ACTR2 | 1.24 | Q5M7U6 | ARP2 | Actin-related protein 2 |
| MYH10 | 1.15 | Q9JLT0 | MYH10 | Myosin-10 |
| ACTB | 1.10 | P60711 | ACTB | Actin; cytoplasmic 1 |
| Neuronal structure and development/reorganization | ||||
| BCAS1 | 2.39 | Q3ZB98 | BCAS1 | Breast carcinoma-amplified sequence 1 homolog |
| PRPH | 2.22 | P21807 | PERI | Peripherin |
| VIM | 1.93 | P31000 | VIME | Vimentin |
| ODF4 | 1.74 | Q6AXT9 | ODFP4 | Outer dense fiber protein 4 |
| MAG | 1.66 | P07722 | MAG | Myelin-associated glycoprotein precursor |
| APP | 1.61 | P08592 | A4 | Amyloid beta A4 protein precursor |
| GAP43 | 1.56 | P07936 | NEUM | Neuromodulin |
| ERMN | 1.54 | Q5RJL0 | ERMIN | Ermin |
| DPYSL3 | 1.47 | Q62952 | DPYL3 | Dihydropyrimidinase-related protein 3 |
| BCAN | 1.44 | P55068 | PGCB | Brevican core protein precursor |
| NEFL | 1.42 | P19527 | NFL | Neurofilament light polypeptide |
| CADM2 | 1.41 | Q1WIM2 | CADM2 | Cell adhesion molecule 2 precursor |
| NEFH | 1.41 | P16884 | NFH | Neurofilament heavy polypeptide |
| NRCAM | 1.39 | P97686 | NRCAM | Neuronal cell adhesion molecule precursor |
| BASP1 | 1.33 | Q05175 | BASP | Brain acid soluble protein 1 |
| NEFM | 1.29 | P12839 | NFM | Neurofilament medium polypeptide |
| MBP | 1.27 | P02688 | MBP | Myelin basic protein S |
| INA | 1.24 | P23565 | AINX | Alpha-internexin |
| MAP1A | 1.24 | P34926 | MAP1A | Microtubule-associated protein 1A |
| CNTN1 | 1.23 | Q63198 | CNTN1 | Contactin-1 precursor |
| MAP1B | 1.17 | P15205 | MAP1B | Microtubule-associated protein 1B |
| MAP2 | 1.15 | P15146 | MAP2 | Microtubule-associated protein 2 |
| PLEC | 1.11 | P30427 | PLEC1 | Plectin-1 |
| Neuronal transport and neurotransmitter action | ||||
| CHGB | 3.11 | O35314 | SCG1 | Secretogranin-1 precursor |
| TMED10 | 2.46 | Q63584 | TMEDA | Transmembrane emp24 domain-containing protein 10 precursor |
| DYNC1I2 | 1.98 | Q62871 | DC1I2 | Cytoplasmic dynein 1 intermediate chain 2 |
| CPNE9 | 1.83 | Q5BJS7 | CPNE9 | Copine-9 |
| USO1 | 1.77 | P41542 | USO1 | General vesicular transport factor p115 |
| HOMER3 | 1.49 | Q9Z2X5 | HOME3 | Homer protein homolog 3 |
| PACSIN1 | 1.20 | Q9Z0W5 | PACN1 | Protein kinase C and casein kinase substrate in neurons protein |
| BSN | 1.20 | O88778 | BSN | Protein bassoon |
| HSPA5 | 1.18 | P06761 | GRP78 | 78 kDa glucose-regulated protein precursor |
| NSF | 1.15 | Q9QUL6 | NSF | Vesicle-fusing ATPase |
| SYN1 | 1.08 | P09951 | SYN1 | Synapsin-1 |
| Other | ||||
| LONP2 | 4.67 | Q3MIB4 | LONP2 | Peroxisomal Lon protease homolog 2 |
| NPTXR | 3.54 | O35764 | NPTXR | Neuronal pentraxin receptor |
| HBB | 3.19 | P02091 | HBB1 | Hemoglobin subunit beta-1 |
| SLC6A6 | 3.06 | P31643 | SC6A6 | Sodium- and chloride-dependent taurine transporter |
| unmapped | 2.86 | P01836 | KACA | Ig kappa chain C region; A allele |
| PRSS2 | 2.65 | P00763 | TRY2 | Anionic trypsin-2 precursor |
| PZP | 2.24 | Q63041 | A1M | Alpha-1-macroglobulin precursor |
| C3 | 2.21 | P01026 | CO3 | Complement C3 precursor |
| CST3 | 2.18 | P14841 | CYTC | Cystatin-C precursor |
| LXN | 2.10 | Q64361 | LXN | Latexin |
| DDX46 | 1.96 | Q62780 | DDX46 | Probable ATP-dependent RNA helicase DDX46 |
| EIF3B | 1.95 | Q4G061 | EIF3B | Eukaryotic translation initiation factor 3 subunit B |
| DUSP4 | 1.95 | Q62767 | DUS4 | Dual specificity protein phosphatase 4 |
| RAP1B | 1.93 | Q62636 | RAP1B | Ras-related protein Rap-1b precursor |
| ATP4A | 1.92 | P09626 | ATP4A | Potassium-transporting ATPase alpha chain 1 |
| SOX10 | 1.88 | O55170 | SOX10 | Transcription factor SOX-10 |
| HIST1H1D | 1.85 | P15865 | H12 | Histone H1.2 |
| LMNA | 1.81 | P48679 | LMNA | Lamin-A |
| RPS20 | 1.80 | P60868 | RS20 | 40S ribosomal protein S20 |
| PTGES3 | 1.78 | P83868 | TEBP | Prostaglandin E synthase 3 |
| GFAP | 1.75 | P47819 | GFAP | Glial fibrillary acidic protein |
| LRRC8E | 1.74 | Q3KRC6 | LRC8E | Leucine-rich repeat-containing protein 8E |
| ADCY8 | 1.73 | P40146 | ADCY8 | Adenylate cyclase type 8 |
| CLU | 1.73 | P05371 | CLUS | Clusterin precursor |
| ALB | 1.69 | P02770 | ALBU | Serum albumin precursor |
| NDUFS4 | 1.68 | Q5XIF3 | NDUS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4; mitochondrial |
| ITM2B | 1.67 | Q5XIE8 | ITM2B | Integral membrane protein 2B |
| SSRP1 | 1.66 | Q04931 | SSRP1 | FACT complex subunit SSRP1 |
| PPP5C | 1.64 | P53042 | PPP5 | Serine/threonine-protein phosphatase 5 |
| GSK3B | 1.61 | P18266 | GSK3B | Glycogen synthase kinase-3 beta |
| RPL17 | 1.59 | P24049 | RL17 | 60S ribosomal protein L17 |
| PGRMC1 | 1.59 | P70580 | PGRC1 | Membrane-associated progesterone receptor component 1 |
| PDIA4 | 1.55 | P38659 | PDIA4 | Protein disulfide-isomerase A4 precursor |
| GM10117 | 1.55 | P17077 | RL9 | 60S ribosomal protein L9 |
| NME2 | 1.54 | P19804 | NDKB | Nucleoside diphosphate kinase B |
| HBA1 | 1.52 | P01946 | HBA | Hemoglobin subunit alpha-1/2 |
| KHSRP | 1.52 | Q99PF5 | FUBP2 | Far upstream element-binding protein 2 |
| PTK2B | 1.51 | P70600 | FAK2 | Protein tyrosine kinase 2 beta |
| RPLP2 | 1.51 | P02401 | RLA2 | 60S acidic ribosomal protein P2 |
| PDIA6 | 1.50 | Q63081 | PDIA6 | Protein disulfide-isomerase A6 precursor |
| PIP4K2B | 1.49 | O88377 | PI42B | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta |
| STIP1 | 1.49 | O35814 | STIP1 | Stress-induced-phosphoprotein 1 |
| GPD1 | 1.46 | O35077 | GPDA | Glycerol-3-phosphate dehydrogenase [NAD+]; cytoplasmic |
| AKAP12 | 1.45 | Q5QD51 | AKA12 | A-kinase anchor protein 12 |
| RNPEP | 1.41 | O09175 | AMPB | Aminopeptidase B |
| DBI | 1.40 | P11030 | ACBP | Acyl-CoA-binding protein |
| ANXA3 | 1.40 | P14669 | ANXA3 | Annexin A3 |
| HCG 25371 | 1.39 | Q5M9I5 | QCR6 | Cytochrome b-c1 complex subunit 6; mitochondrial precursor |
| HNRNPH1 | 1.39 | Q8VHV7 | HNRH1 | Heterogeneous nuclear ribonucleoprotein H |
| ABI1 | 1.39 | Q9QZM5 | ABI1 | Abl interactor 1 |
| ACSBG1 | 1.39 | Q924N5 | ACBG1 | Long-chain-fatty-acid CoA ligase ACSBG1 |
| APOE | 1.38 | P02650 | APOE | Apolipoprotein E precursor |
| PLCB1 | 1.37 | P10687 | PLCB1 | 1-phosphatidylinositol-4;5-bisphosphate phosphodiesterase beta |
| CA2 | 1.36 | P27139 | CAH2 | Carbonic anhydrase 2 |
| THY1 | 1.35 | P01830 | THY1 | Thy-1 membrane glycoprotein precursor |
| HSP90AB1 | 1.33 | P34058 | HS90B | Heat shock protein HSP 90-beta |
| IDH3B | 1.32 | Q68FX0 | IDH3B | Isocitrate dehydrogenase [NAD] subunit beta; mitochondrial precursor |
| PPIA | 1.30 | P10111 | PPIA | Peptidyl-prolyl cis-trans isomerase A |
| ENO3 | 1.30 | P15429 | ENOB | Beta-enolase |
| ATP5C1 | 1.29 | P35435 | ATPG | ATP synthase subunit gamma; mitochondrial |
| ATP6V1E1 | 1.29 | Q6PCU2 | VATE1 | Vacuolar proton pump subunit E 1 |
| GOT1 | 1.29 | P13221 | AATC | Aspartate aminotransferase; cytoplasmic |
| NDUFV2 | 1.28 | P19234 | NDUV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2; mitochondrial |
| HSPA2 | 1.27 | P14659 | HSP72 | Heat shock-related 70 kDa protein 2 |
| UCHL1 | 1.26 | Q00981 | UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| YWHAH | 1.25 | P68511 | 1433F | 14-3-3 protein eta |
| PRKCA | 1.25 | P05696 | KPCA | Protein kinase C alpha type |
| TKT | 1.24 | P50137 | TKT | Transketolase |
| HYOU1 | 1.24 | Q63617 | HYOU1 | Hypoxia up-regulated protein 1 precursor |
| CCT5 | 1.22 | Q68FQ0 | TCPE | T-complex protein 1 subunit epsilon |
| PRDX6 | 1.21 | O35244 | PRDX6 | Peroxiredoxin-6 |
| SPTAN1 | 1.21 | P16086 | SPTA2 | Spectrin alpha chain; brain |
| CCDC92 | 1.17 | P09606 | GLNA | Glutamine synthetase |
| PEA15 | 1.12 | Q5U318 | PEA15 | Astrocytic phosphoprotein PEA-15 |