Table 2.
Proteins Downregulated by Traumatic Brain Injury
| IPA name | Ratio | Accession no. | Uniprot name | Protein name |
|---|---|---|---|---|
| Glycolysis | ||||
| HK1 | 0.88 | P05708 | HXK1 | Hexokinase-1 |
| ALDOC | 0.68 | P09117 | ALDOC | Fructose-bisphosphate aldolase C |
| TPI1 | 0.89 | P48500 | TPIS | Triosephosphate isomerase |
| PGAM1 | 0.82 | P25113 | PGAM1 | Phosphoglycerate mutase 1 |
| ENO1 | 0.85 | P04764 | ENOA | Alpha-enolase |
| PKM2 | 0.93 | P11980 | KPYM | Pyruvate kinase isozymes M1/M2 |
| Krebs cycle | ||||
| LDHA | 0.89 | P04642 | LDHA | L-lactate dehydrogenase A chain |
| PDHB | 0.62 | P49432 | ODPB | Pyruvate dehydrogenase E1 component subunit beta; mitochondrial |
| ACO2 | 0.93 | Q9ER34 | ACON | Aconitate hydratase; mitochondrial precursor |
| Oxidative phosphorylation/electron transport chain | ||||
| NDUFA10 | 0.76 | Q561S0 | NDUAA | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 |
| NDUFA9 | 0.89 | Q5BK63 | NDUA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 |
| SDHA | 0.88 | Q920L2 | DHSA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial |
| UQCRC2 | 0.84 | P32551 | QCR2 | Cytochrome b-c1 complex subunit 2; mitochondrial precursor |
| ATP synthesis and transport | ||||
| SLC25A4 | 0.67 | Q05962 | ADT1 | ADP/ATP translocase 1 |
| ATP5O | 0.39 | Q06647 | ATPO | ATP synthase subunit O; mitochondrial precursor |
| ATP5F1 | 0.67 | P19511 | AT5F1 | ATP synthase subunit b; mitochondrial precursor |
| ATP5A1 | 0.85 | P15999 | ATPA | ATP synthase subunit alpha; mitochondrial precursor |
| ATP5B | 0.89 | P10719 | ATPB | ATP synthase subunit beta; mitochondrial precursor |
| ATP1A1 | 0.66 | P06685 | AT1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 precursor |
| ATP1A3 | 0.85 | P06687 | AT1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 |
| Calcium signaling and homeostasis | ||||
| PPP3R1 | 0.58 | P63100 | CANB1 | Calcineurin subunit B isoform 1 |
| CAMK2D | 0.49 | P15791 | KCC2D | Calcium/calmodulin-dependent protein kinase type II delta chain |
| CALM1 | 0.56 | P62161 | CALM | Calmodulin |
| ATP2B2 | 0.73 | P11506 | AT2B2 | Plasma membrane calcium-transporting ATPase 2 |
| ATP2B3 | 0.74 | Q64568 | AT2B3 | Plasma membrane calcium-transporting ATPase 3 |
| SLC8A1 | 0.67 | Q01728 | NAC1 | Sodium/calcium exchanger 1 precursor |
| Other | ||||
| ZNF22 | 0.21 | Q9ERU2 | ZNF22 | Zinc finger protein 22 |
| MAPRE1 | 0.26 | Q66HR2 | MARE1 | Microtubule-associated protein RP/EB family member 1 |
| DYNC2H1 | 0.27 | Q9JJ79 | DYHC2 | Cytoplasmic dynein 2 heavy chain 1 |
| RAB1B | 0.31 | P10536 | RAB1B | Ras-related protein Rab-1B |
| RPL23 | 0.34 | P62832 | RL23 | 60S ribosomal protein L23 |
| RALA | 0.43 | P63322 | RALA | Ras-related protein Ral-A precursor |
| RPL22 | 0.48 | P47198 | RL22 | 60S ribosomal protein L22 |
| DPYSL4 | 0.48 | Q62951 | DPYL4 | Dihydropyrimidinase-related protein 4 |
| SLC1A2 | 0.50 | P31596 | EAA2 | Excitatory amino acid transporter 2 |
| SFXN5 | 0.51 | Q8CFD0 | SFXN5 | Sideroflexin-5 |
| PLS3 | 0.52 | Q63598 | PLST | Plastin-3 |
| CKMT1B | 0.53 | P25809 | KCRU | Creatine kinase; ubiquitous mitochondrial precursor |
| SFXN1 | 0.55 | Q63965 | SFXN1 | Sideroflexin-1 |
| DSTN | 0.56 | Q7M0E3 | DEST | Destrin |
| PRDX2 | 0.57 | P35704 | PRDX2 | Peroxiredoxin-2 |
| ANXA5 | 0.58 | P14668 | ANXA5 | Annexin A5 |
| VDAC3 | 0.58 | Q9R1Z0 | VDAC3 | Voltage-dependent anion-selective channel protein 3 |
| ALDH5A1 | 0.59 | P51650 | SSDH | Succinate-semialdehyde dehydrogenase |
| ASRGL1 | 0.59 | Q8VI04 | ASGL1 | L-asparaginase |
| HDHD2 | 0.62 | Q6AYR6 | HDHD2 | Haloacid dehalogenase-like hydrolase domain-containing protein |
| VAMP2 | 0.63 | P63045 | VAMP2 | Vesicle-associated membrane protein 2 |
| TUBB3 | 0.65 | Q4QRB4 | TBB3 | Tubulin beta-3 chain |
| EEF1A2 | 0.66 | P62632 | EF1A2 | Elongation factor 1-alpha 2 |
| ACAT1 | 0.67 | P17764 | THIL | Acetyl-CoA acetyltransferase; mitochondrial precursor |
| RHOB | 0.67 | P62747 | RHOB | Rho-related GTP-binding protein RhoB precursor |
| PHB2 | 0.74 | Q5XIH7 | PHB2 | Prohibitin-2 |
| SYN2 | 0.74 | Q63537 | SYN2 | Synapsin-2 |
| AK1 | 0.75 | P39069 | KAD1 | Adenylate kinase isoenzyme 1 |
| TUBB2C | 0.77 | Q6P9T8 | TBB2C | Tubulin beta-2C chain |
| RAB3C | 0.78 | P62824 | RAB3C | Ras-related protein Rab-3C |
| PFN1 | 0.78 | P62963 | PROF1 | Profilin-1 |
| AP2A2 | 0.78 | P18484 | AP2A2 | AP-2 complex subunit alpha-2 |
| S100A1 | 0.79 | P35467 | S10A1 | Protein S100-A1 |
| HCG 2023776 | 0.80 | P04256 | ROA1 | Heterogeneous nuclear ribonucleoprotein A1 |
| YWHAZ | 0.80 | P63102 | 1433Z | 14-3-3 protein zeta/delta |
| EIF5A | 0.81 | Q3T1J1 | IF5A1 | Eukaryotic translation initiation factor 5A-1 |
| GDA | 0.81 | Q9WTT6 | GUAD | Guanine deaminase |
| TNR | 0.81 | Q05546 | TNR | Tenascin-R precursor |
| HSPD1 | 0.84 | P63039 | CH60 | 60 kDa heat shock protein; mitochondrial precursor |
| TUBA1B | 0.85 | Q6P9V9 | TBA1B | Tubulin alpha-1B chain |
| RAB3A | 0.86 | P63012 | RAB3A | Ras-related protein Rab-3A |
| GNB1 | 0.86 | P54311 | GBB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta |
| YWHAE | 0.87 | P62260 | 1433E | 14-3-3 protein epsilon |
| GNAI1 | 0.89 | P10824 | GNAI1 | Guanine nucleotide-binding protein G(i); alpha-1 subunit |
| TUBB2A | 0.89 | P85108 | TBB2A | Tubulin beta-2A chain |
| YWHAB | 0.89 | P35213 | 1433B | 14-3-3 protein beta/alpha |
| CNP | 0.90 | P13233 | CN37 | 2′;3′-cyclic-nucleotide 3′-phosphodiesterase |
| ENO2 | 0.92 | P07323 | ENOG | Gamma-enolase |
| TUBA1A | 0.94 | P68370 | TBA1A | Tubulin alpha-1A chain |
| STXBP1 | 0.95 | P61765 | STXB1 | Syntaxin-binding protein 1 |