Table 3.

Associated Network Functions

All 1002 identified and quantified proteins	Scorea
Cell morphology, cellular assembly and organization, genetic disorder	41
Protein synthesis, cancer, gastrointestinal disease	41
Molecular transport, small molecule biochemistry, cellular assembly/organization	38
Cell signaling, cellular assembly and organization, cellular function/maintenance	38
Cellular assembly and organization, genetic disorder, metabolic disease	38
124 Upregulated proteins
Cellular assembly, organization, function; nervous system development	41
Cardiovascular disease, neurological disease, amino acid metabolism	40
Cellular assembly, organization, function; neurological disease	37
Nervous system development and function, cell death, cellular development	30
Nucleic acid metabolism, small molecule biochemistry, molecular transport	29
76 Downregulated proteins
Energy production, nucleic acid metabolism, small molecule biochemistry	64
Cell death, energy production, molecular transport	46
Carbohydrate metabolism, infectious disease, inflammatory disease	37
Cell death, cell signaling, molecular transport	21

^aRank of networks according to their degree of relevance to the total network eligible molecules in the dataset of proteins taking into account the total number of molecules in the Ingenuity Knowledge Base that could potentially be included in networks.