Table 4.
Top Biological Functions of Differentially-Regulated Proteins
| Name | p Valuea | No. proteinsb |
|---|---|---|
| Molecular and cellular function Upregulated | ||
| Cellular assembly and organization | 1.16E-13–7.95E-03 | 50 |
| Cell morphology | 6.58E-11–7.95E-03 | 43 |
| Cellular function and maintenance | 1.88E-08–7.95E-03 | 31 |
| Cellular compromise | 1.70E-07–7.95E-03 | 23 |
| Cell-to-cell signaling and interaction | 4.89E-07–7.95E-03 | 29 |
| Downregulated | ||
| Carbohydrate metabolism | 7.34E-08–3.90E-02 | 11 |
| Energy production | 2.83E-07–3.90E-02 | 13 |
| Nucleic acid metabolism | 2.83E-07–4.85E-02 | 19 |
| Small molecule biochemistry | 2.83E-07–4.96E-02 | 37 |
| DNA replication, recombination, and repair | 2.04E-06–3.68E-02 | 7 |
| Physiological system development and function | ||
| Upregulated | ||
| Nervous system development and function | 1.45E-13–7.95E-03 | 46 |
| Behavior | 2.84E-04–3.21E-04 | 8 |
| Organismal survival | 3.65E-04–1.98E-03 | 7 |
| Cardiovascular system development and function | 3.72E-04–7.95E-03 | 9 |
| Tissue development | 3.72E-04–7.95E-03 | 18 |
| Downregulated | ||
| Nervous system development and function | 2.20E-04–4.85E-02 | 15 |
| Cardiovascular system development and function | 5.01E-04–3.90E-02 | 6 |
| Organ morphology | 5.01E-04–3.42E-02 | 4 |
| Hematological system development and function | 4.96E-03–3.90E-02 | 4 |
| Skeletal, muscular system development, function | 4.96E-03–3.90E-02 | 8 |
a
Likelihood that the association between the proteins in our entire dataset and a related function is due to random association.
b
Number of proteins within each subcategory of functions.