Table 5.
Canonical Pathways of Differentially-Regulated Proteins
| Name | p Valuea | Ratiob |
|---|---|---|
| Upregulated | ||
| Protein kinase A signaling | 1.35E-04 | 10/319 (0.031) |
| RhoA signaling | 2.09E-04 | 6/110 (0.055) |
| Caveolar-mediated endocytosis | 3.03E-04 | 5/85 (0.059) |
| Downregulated | ||
| Glycolysis/gluconeogenesis | 4.70E-11 | 10/142 (0.07) |
| Oxidative phosphorylation | 7.40E-07 | 8/165 (0.048) |
| 14-3-3-Mediated signaling | 1.17E-06 | 7/114 (0.061) |
| Pyruvate metabolism | 4.70E-05 | 5/149 (0.034) |
a
Measure of the likelihood that the association between the functional analysis proteins in this experiment and a given pathway is due to random chance.
b
Number of proteins that participate in a canonical pathway divided by the total number of proteins in the IPA Knowledge Base of Canonical Pathways.