Table 1.
Clinical and laboratory data of eight CD patients originating from the initial group of 450 FDR that disclosed seroconversion (Group II)
| $ Pts | Kinship | Age at 1 st test (y) | Age at 2 nd test (y) | Interval between 1 st and 2 nd test (m) | tTG | EMA | HLA | # Marsh | Symptoms and associated disorders |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
Sister |
6 |
7 |
12 |
35.9 |
Pos |
DQA1*0501 |
I |
Irritability, constipation, recurrent abdominal pain |
| DQB1*0201 | |||||||||
| 2 |
Sister (twin) |
12 |
16 |
54 |
35.1 |
Neg |
DQA1*0501 |
ND |
Recurrent abdominal pain, frequent joint pain |
| DQB1*0201 | |||||||||
| DQA1*0301 | |||||||||
| DQB1*0302 | |||||||||
| 3 |
Sister |
30 |
37 |
88 |
123.6 |
Pos |
DQA1*0501 |
III |
Bouts of diarrhea, recurrent abdominal pain, bloating, anemia |
| DQB1*0201 | |||||||||
| 4 |
Mother |
30 |
37 |
84 |
46.5 |
Neg |
DQA1*0501 |
ND |
Bouts of diarrhea, aphthous ulcers, bloating, joint pain |
| DQB1*0201 | |||||||||
| 5 |
Sister |
32 |
35 |
38 |
57,1 |
Neg |
DQA1*0501 |
ND |
Asymptomatic |
| DQB1*0201 | |||||||||
| 6 |
Sister |
37 |
39 |
26 |
81.7 |
Pos |
DQA1*0501 |
I |
Bloating, constipation, aphtous ulcers, fatigue |
| DQB1*0201 | |||||||||
| 7 |
Sister and daughter |
37 |
44 |
89 |
95.6 |
Pos |
DQB1*0201 |
III |
Asymptomatic |
| DQA1*0301 | |||||||||
| DQB1*0302 | |||||||||
| 8 |
Father |
67 |
75 |
89 |
65.9 |
Pos |
DQA1*0501 |
II |
Asymptomatic |
| DQB1*0201 |
$Patients #Marsh Classification.