Table 4.
Twenty KEGG and PANTHER pathways applied to the 500 hypermethylated genes in the thalamus
|
Category |
Pathway |
Count |
Fold |
Benjamini |
|
|---|---|---|---|---|---|
| Enrichment | P value | P value | |||
| KEGG_PATHWAY |
Long-term potentiation |
9 |
5.270 |
2.58 × 10-4 |
0.033 |
| KEGG_PATHWAY |
MAPK signaling pathway |
16 |
2.475 |
0.002 |
0.108 |
| PANTHER_PATHWAY |
Alzheimer disease-amyloid secretase pathway |
9 |
3.872 |
0.002 |
0.147 |
| KEGG_PATHWAY |
Long-term depression |
7 |
3.985 |
0.008 |
0.283 |
| KEGG_PATHWAY |
GnRH signaling pathway |
8 |
3.380 |
0.009 |
0.250 |
| KEGG_PATHWAY |
Calcium signaling pathway |
11 |
2.360 |
0.017 |
0.360 |
| KEGG_PATHWAY |
Vascular smooth muscle contraction |
8 |
2.732 |
0.026 |
0.433 |
| KEGG_PATHWAY |
Wnt signaling pathway |
9 |
2.476 |
0.028 |
0.405 |
| KEGG_PATHWAY |
Melanogenesis |
7 |
2.869 |
0.034 |
0.428 |
| PANTHER_PATHWAY |
TGF-beta signaling pathway |
10 |
2.080 |
0.046 |
0.876 |
| KEGG_PATHWAY |
Ubiquitin mediated proteolysis |
8 |
2.411 |
0.046 |
0.496 |
| PANTHER_PATHWAY |
Endogenous_cannabinoid_signaling |
4 |
4.832 |
0.047 |
0.757 |
| PANTHER_PATHWAY |
PDGF signaling pathway |
11 |
1.930 |
0.052 |
0.698 |
| KEGG_PATHWAY |
Glycerophospholipid metabolism |
5 |
3.059 |
0.078 |
0.654 |
| PANTHER_PATHWAY |
Endothelin signaling pathway |
7 |
2.290 |
0.080 |
0.772 |
| PANTHER_PATHWAY |
Notch signaling pathway |
5 |
2.963 |
0.084 |
0.727 |
| PANTHER_PATHWAY |
Metabotropic glutamate receptor group II pathway |
5 |
2.908 |
0.088 |
0.691 |
| KEGG_PATHWAY |
Neurotrophin signaling pathway |
7 |
2.207 |
0.095 |
0.692 |
| PANTHER_PATHWAY |
Ionotropic glutamate receptor pathway |
5 |
2.804 |
0.098 |
0.682 |
| KEGG_PATHWAY | N-Glycan biosynthesis | 4 | 3.564 | 0.100 | 0.679 |