Table 5. In Vitro Anticancer Activity of the Compounds 1–8 and Three Osmium Analogues 1*, 4*, and 5*a.
| IC50 values ± SD (μM) |
partition
coefficients |
||||
|---|---|---|---|---|---|
| complex | A549 | CH1 | SW480 | log D7.4 | log D7.4b |
| 1 | 196 ± 27 | 7.5 ± 1.2 | 39 ± 3 | –2.04 ± 0.08 | |
| 2 | >320 | 12 ± 2 | 47 ± 3 | –1.63 ± 0.08 | –1.47 ± 0.11 |
| 3 | >320 | 27 ± 3 | 53 ± 2 | –1.13 ± 0.02 | –1.31 ± 0.07 |
| 4 | >320 | 20 ± 3 | 54 ± 10 | –1.55 ± 0.08 | |
| 5 | 108 ± 5 | 13 ± 1 | 20 ± 3 | –1.43 ± 0.08 | |
| 6 | >320 | 13 ± 2 | 63 ± 10 | –1.77 ± 0.12 | |
| 7 | >320 | 23 ± 2 | 71 ± 15 | –1.75 ± 0.02 | |
| 8 | >320 | 17 ± 3 | 38 ± 12 | –1.16 ± 0.02 | |
| 1*c | 629 ± 13 | 89 ± 11 | 140 ± 36 | ||
| 4*c | >320 | 114 ± 37 | 237 ± 47 | ||
| 5*c | >640 | 148 ± 38 | 274 ± 40 | ||
a
In human ovarian (CH1), colon (SW480), and non-small cell lung (A549) carcinoma cell lines, with log D7.4 values for the complexes; 50% inhibitory concentrations (means ± standard deviations), obtained by the MTT assay (exposure time 96 h), log D7.4 values were estimated in 0.02 M HEPES; T = 298.0 K.
b
In the presence of 0.1 M KCl.
c
Data taken from reference (13).