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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nat Immunol. 2013 Dec 1;15(1):98–108. doi: 10.1038/ni.2768

Fig. 8. Blimp-1 deficiency specifically impairs intestinal mDP frequencies.

Fig. 8

a) Subset composition of gut-associated cDCs derived from Blimp-1fl/fl littermate controls (wt) versus Blimp-1fl/fl crossed to CD11c-cre mice (DCBlimp-1KO). Cells were gated on the live, lineage negative (CD3, B220, NK1.1), CD11chi, MHCIIhi population. Representative for two individual stainings of three pairs each and three individual stainings of three pairs each.

b) Subset composition of cDCs populations defined by CD8α and CD11b expression from the same mice as in c) in spleens and peripheral LNs.

c) Ratios of mDP to mSP DCs within CD11chiMHCIIhi, lineage negative (CD3, B220, NK1.1) live cells of mLNs and SI LP of DCBlimpKO (black bars) and littermate controls (grey bars); three mice each, mLN: **p = 0.005, SI LP: *p = 0.03