Table 1.

Clinical Parameters and Thyroid Function Tests in the Three Groups

	Healthy Controls	L-T4 Euthyroid	L-T4 Suppressed	P Value
n	20	35	24
Age, y	40.0 ± 2.2	41.5 ± 1.7	38.9 ± 1.8	.58
WAIS-R	10.25 ± 0.62	10.49 ± 0.30	10.17 ± 0.45	.82
Years in school	16.1 ± 0.5	16.7 ± 0.5	15.9 ± 0.6	.69
Estrogen status	60% Pre-none, 20% Pre-on, 20% Post-none	60% Pre-none, 17% Pre-on, 23% Post-none	67% Pre-none, 17% Pre-on, 17% Post-none	.98
BMI, kg/m2	29.1 ± 1.7	28.1 ± 0.8	25.6 ± 0.9	.09
L-T4 dose, μg/kg	NA	1.46 ± 0.09	1.93 ± 0.11c	.001
TSH, mU/L	2.16 ± 0.20	1.83 ± 0.16	0.13 ± 0.02a,c	<.0001
fT4, ng/dL	1.38 ± 0.06	1.61 ± 0.06a	2.26 ± 0.09a,c	<.0001
fT3, pg/dL	243 ± 9	217 ± 6b	239 ± 7d	.02

Abbreviations: Pre-none, premenopausal, no hormone treatment; Pre-on, premenopausal on hormone treatment; Post-none, postmenopausal, no hormone treatment; NA, not applicable. Data are expressed as mean ± SEM, unless otherwise specified.

^aSignificantly different than healthy control group at level 0.01 by post hoc tests.

^bSignificantly different than healthy control group at level 0.05 by post hoc tests.

^cSignificantly different than L-T4 euthyroid group at level 0.01 by post hoc tests.

^dSignificantly different than L-T4 euthyroid group at level 0.05 by post hoc tests.