Table 1.
Characteristics of the women with GD and HT who reported or did not report a period of infertility.
| Characteristics | Infertility | No infertility | P value |
|---|---|---|---|
| Graves' disease n (%) | 101 (52.3) | 92 (47.7) | |
| Agea | 44.3 (9.4) | 42.2 (9.3) | NSb |
| Age at menarche (years)a | 12.8 (1.8) | 12.6 (1.6) | NSb |
| Age at sexual debut (years)a | 17.6 (3.8) | 17.5 (3.7) | NSb |
| Age at diagnosis (years)a | 36.5 (9.8) | 35.8 (9.1) | NSb |
| Time of the disease (years)a | 7.8 (5.9) | 6.3 (4.6) | NSb |
| Exophthalmos | 57 (56.4) | 60 (65.2) | NSc |
| Goiter volume (cm3)a | 26.4 (22.2) | 26.2 (18.9) | NSa |
| Thyroid nodule | 28 (31.4) | 25 (29.7) | NSc |
| Anti-TPO | 87 (87.9) | 72 (84.7) | NSc |
| Anti-Tg | 61 (61.6) | 52 (58.4) | NSc |
| Other autoimmune diseases | 11 (10.9) | 11 (11.9) | NSc |
| Family history of thyroid disease | |||
| Graves' disease | 14 (13.8) | 14 (15.5) | NSc |
| Hashimoto's thyroiditis | 13 (12.8) | 7 (7.8) | NSc |
| Family history of other autoimmune diseases | 47 (46.5) | 38 (42.2) | NSc |
| Hashimoto's thyroiditis n (%) | 31 (47.0) | 35 (53.0) | |
| Age (years)a | 44.7 (10.4) | 46.2 (10.8) | NSb |
| Age at menarche (years)a | 12.4 (2.0) | 12.4 (1.6) | NSb |
| Age at sexual debut (years)a | 18.5 (3.8) | 17.4 (3.1) | NSb |
| Age at diagnosis (years)a | 39.2 (10.6) | 37.1 (11.4) | NSb |
| Time of the disease (years)a | 5.5 (4.2) | 9.1 (5.6) | 0.004b |
| Goiter | 10 (33.3) | 13 (39.4) | NSc |
| Goiter volume (cm3)a | 17.8 (22.3) | 16.3 (11.8) | NSb |
| Thyroid nodule | 15 (50.0) | 10 (30.3) | NSc |
| Anti-TPO | 27 (90.0) | 33 (94.3) | NSd |
| Anti-Tg | 27 (87.1) | 29 (82.8) | NSd |
| Other autoimmune diseases | 4 (12.9) | 3 (8.6) | NSd |
| Family history of thyroid disease | |||
| Graves' disease | 2 (6.7) | 5 (14.3) | NSd |
| Hashimoto's thyroiditis | 11 (36.7) | 10 (28.6) | NSc |
| Family history of other autoimmune diseases | 18 (60.0) | 18 (51.4) | NSc |
“Infertility” and “No infertility” groups refer, respectively, to the group of women who reported a period of infertility and the group of women who did not.
NS: not significant; avalues consist of means ± standard deviation of the mean; bMann-Whitney test; cchi-square test; dFisher's exact test; anti-TPO: antithyroid peroxidase antibodies; anti-Tg: antithyroglobulin antibodies.