Table 3. Hazard Ratios from Cox Regression Models for Baseline Troponin Assessed by Contemporary-Sensitivity, High-Sensitivity and Super-Sensitivity Assays for Various Endpoints after Adjustment for the Framingham Risk Score.

		Continuous		Categorical
Event	Troponin	HR (95% CI)	p value	HR (95% CI)	p value
MACE	cs-cTnI	1.07 (0.97–1.17)	ns	1.22 (0.95–1.57)	ns
	hs-cTnI	1.12 (1.05–1.19)	<0.001	1.24 (0.91–1.69)	ns
	ss-cTnI	1.18 (1.11–1.25)	<0.001	2.10 (1.21–3.63)	0.008
CVD	cs-cTnI	1.07 (0.96–1.20)	ns	1.20 (0.87–1.64)	ns
	hs-cTnI	1.09 (1.01–1.18)	0.032	1.08 (0.74–1.58)	ns
	ss-cTnI	1.15 (1.07–1.24)	<0.001	1.95 (0.97–3.93)	ns
MI	cs-cTnI	1.17 (0.10–1.39)	ns	1.52 (0.90–2.57)	ns
	hs-cTnI	1.17 (1.04–1.30)	0.006	1.11 (0.59–2.10)	ns
	ss-cTnI	1.24 (1.11–1.39)	<0.001	2.85 (0.69–11.68)	ns
HF	cs-cTnI	1.10 (0.96–1.26)	ns	1.31 (0.90–1.89)	ns
	hs-cTnI	1.19 (1.10–1.30)	<0.001	1.68 (1.04–2.72)	0.036
	ss-cTnI	1.28 (1.18–1.39)	<0.001	2.59 (1.15–5.82)	0.02
Stroke	cs-cTnI	1.04 (0.86–1.26)	ns	1.02 (0.63–1.65)	ns
	hs-cTnI	1.09 (0.96–1.23)	ns	0.99 (0.55–1.78)	ns
	ss-cTnI	1.14 (1.01–1.28)	0.032	1.97 (0.64–6.09)	ns
Death	cs-cTnI	1.03 (0.89–1.18)	ns	1.04 (0.73–1.47)	ns
	hs-cTnI	1.06 (0.98–1.14)	ns	1.40 (0.96–2.05)	ns
	ss-cTnI	1.06 (0.98–1.15)	ns	1.02 (0.64–1.64)	ns

Shown are the hazard ratios for continuous troponin concentration per 1-SD increment and for categorical troponin concentration, comparing the highest with the lowest defined category. Please see the footnote to Table 2 for cut points of the categories.

Abbreviations: MACE = major adverse cardiac events, CVD = cardiovascular disease, MI = myocardial infarction, HF = heart failure, HR = hazard ratio, CI = confidence interval, cs-cTnI = troponin I measured by contemporary-sensitivity assay, hs-cTnI = highly sensitive troponin, ss-cTnI = supersensitive troponin, ns = not significant.