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. 2014 Mar 4;9(3):e90008. doi: 10.1371/journal.pone.0090008

Table 3. Stratification analysis of the lincRNA-NR_024015 rs8506G>A genotypes by selected variables in non-cardia gastric cancer patients and controls.

Cases (N = 438) Controls (N = 727) Adjusted OR (95% CI)a P valueb
GG (%) AG+AA (%) GG (%) AG+AA (%) AG+AA vs. GG
Age(years)
≤60 91 (20.8) 65 (14.8) 194 (26.7) 89 (12.2) 1.56 (1.04–2.34)
>60 135 (30.8) 147 (33.6) 224 (30.8) 220 (30.3) 1.11 (0.82–1.49) 0.19
Sex
Male 148 (33.8) 174 (39.7) 242 (33.3) 249 (34.2) 1.14 (0.86–1.51)
Female 78 (17.8) 38 (8.7) 176 (24.2) 60 (8.3) 1.43 (0.88–2.32) 0.44
Smoking Status
Positive 106 (24.2) 83 (19.0) 168 (23.1) 53 (7.3) 2.48 (1.63–3.78)
Negative 120 (27.4) 129 (29.5) 250 (34.4) 256 (35.2) 1.05 (0.77–1.42) 0.001
Drinking
Positive 118 (26.9) 57 (13.0) 186 (25.6) 81 (11.1) 1.11 (0.74–1.67)
Negative 108 (24.7) 155 (35.4) 232 (31.9) 228 (31.4) 1.46 (1.08–1.98) 0.29
Family history
Positive 15 (3.4) 19 (4.3) 22 (4.0) 29 (4.0) 0.96 (0.40–2.30)
Negative 211 (48.2) 193 (44.1) 396 (54.5) 280 (38.5) 1.29 (1.01–1.66) 0.52
H.pylori status
H. pylori positive 162 (37.0) 160 (36.5) 418 (57.5) 309 (42.5) 1.37 (1.05–1.78)
H. pylori negative 64 (14.6) 52 (11.9) 418 (57.5) 309 (42.5) 1.66 (1.12–2.47) 0.42
TNM stage
I 54 (12.3) 50 (11.5) 418 (57.5) 309 (42.5) 1.25 (0.83–1.89)
II 43 (9.8) 47 (10.7) 418 (57.5) 309 (42.5) 1.48 (0.95–2.29)
III 86 (19.6) 83 (19.0) 418 (57.5) 309 (42.5) 1.31 (0.93–1.83) 0.71
IV 43 (9.8) 32 (7.3) 418 (57.5) 309 (42.5) 1.01 (0.62–1.63)
a

ORs were adjusted for age, sex, smoking, and drinking status of non-cardia gastric cancer in a logistic regression model.

b

P value of the test for multiplicative interaction between stratum-related variables and lincRNA-NR_024015 (rs8506G>A AG+AA vs.GG genotypes).