Table 3. Stratification analysis of the lincRNA-NR_024015 rs8506G>A genotypes by selected variables in non-cardia gastric cancer patients and controls.
Cases (N = 438) | Controls (N = 727) | Adjusted OR (95% CI)a | P valueb | |||||||
GG | (%) | AG+AA | (%) | GG | (%) | AG+AA | (%) | AG+AA vs. GG | ||
Age(years) | ||||||||||
≤60 | 91 | (20.8) | 65 | (14.8) | 194 | (26.7) | 89 | (12.2) | 1.56 (1.04–2.34) | |
>60 | 135 | (30.8) | 147 | (33.6) | 224 | (30.8) | 220 | (30.3) | 1.11 (0.82–1.49) | 0.19 |
Sex | ||||||||||
Male | 148 | (33.8) | 174 | (39.7) | 242 | (33.3) | 249 | (34.2) | 1.14 (0.86–1.51) | |
Female | 78 | (17.8) | 38 | (8.7) | 176 | (24.2) | 60 | (8.3) | 1.43 (0.88–2.32) | 0.44 |
Smoking Status | ||||||||||
Positive | 106 | (24.2) | 83 | (19.0) | 168 | (23.1) | 53 | (7.3) | 2.48 (1.63–3.78) | |
Negative | 120 | (27.4) | 129 | (29.5) | 250 | (34.4) | 256 | (35.2) | 1.05 (0.77–1.42) | 0.001 |
Drinking | ||||||||||
Positive | 118 | (26.9) | 57 | (13.0) | 186 | (25.6) | 81 | (11.1) | 1.11 (0.74–1.67) | |
Negative | 108 | (24.7) | 155 | (35.4) | 232 | (31.9) | 228 | (31.4) | 1.46 (1.08–1.98) | 0.29 |
Family history | ||||||||||
Positive | 15 | (3.4) | 19 | (4.3) | 22 | (4.0) | 29 | (4.0) | 0.96 (0.40–2.30) | |
Negative | 211 | (48.2) | 193 | (44.1) | 396 | (54.5) | 280 | (38.5) | 1.29 (1.01–1.66) | 0.52 |
H.pylori status | ||||||||||
H. pylori positive | 162 | (37.0) | 160 | (36.5) | 418 | (57.5) | 309 | (42.5) | 1.37 (1.05–1.78) | |
H. pylori negative | 64 | (14.6) | 52 | (11.9) | 418 | (57.5) | 309 | (42.5) | 1.66 (1.12–2.47) | 0.42 |
TNM stage | ||||||||||
I | 54 | (12.3) | 50 | (11.5) | 418 | (57.5) | 309 | (42.5) | 1.25 (0.83–1.89) | |
II | 43 | (9.8) | 47 | (10.7) | 418 | (57.5) | 309 | (42.5) | 1.48 (0.95–2.29) | |
III | 86 | (19.6) | 83 | (19.0) | 418 | (57.5) | 309 | (42.5) | 1.31 (0.93–1.83) | 0.71 |
IV | 43 | (9.8) | 32 | (7.3) | 418 | (57.5) | 309 | (42.5) | 1.01 (0.62–1.63) |
ORs were adjusted for age, sex, smoking, and drinking status of non-cardia gastric cancer in a logistic regression model.
P value of the test for multiplicative interaction between stratum-related variables and lincRNA-NR_024015 (rs8506G>A AG+AA vs.GG genotypes).