Table 1.

Characteristics and functions of selected BTB proteins

BTB proteins are involved in diverse biological processes. To date, a functional link to ubiquitin-dependent degradation has only been established in C. elegans for the CUL-3/MEL-26 complex. However, it has recently been shown that CUL-3 interacts with several other BTB proteins (+: positive interaction with Cul3; nd: not determined) in all species. The numbers in parentheses indicate the total number of BTB proteins in the following species: S.p, Schizosaccharomyces pombe; S.c, Saccharomyces cerevisiae; C.e, Caenorhabditis elegans; D.m, Drosophila melanogaster; H.s, Homo sapiens. Bold: BTB proteins for which a link to ubiquitin-dependent degradation is established or emerging.