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. 2014 Mar 4;9(3):e90400. doi: 10.1371/journal.pone.0090400

Figure 11. Distant metastasis in an orthotopic xenograft model of pancreatic cancer.

Figure 11

Ex vivo bioluminescence analysis revealed significantly decreased metastasis to the liver (A), lung (C), and mesenteric lymph nodes (D) of CXCL12-expressing cells compared to GFP-controls. Representative biophotonic images of hepatic metastases are shown in panel B. (**) and (***) denote statistically significant P≤0.01 and P≤0.001, respectively, differences between CXCL12-expressing and control tumor engrafted mice. n = 8–10 mice in each group.