Table 3. Comparison of mean values of DCE parameters in pre- and post-treatment VS and Meningiomas.

		b Compare Drug-Induced Changes of Mean in Two Tumors Wilcoxon Rank-sum Test
Tumor type	a DCE- MRI Para-meters.	Day 0	Day 3	Day 90
VS	MSE	86.7±20.2	63.6±14.0 *	54.4±19.7 *
	MSErel	1.04±0.19	0.77±0.17 *	0.65±0.23 **
	ΣMSE	62.6±14.5	43.7±10.4 *	36.0±14.0 *
	ΣMSErel	0.75±0.14	0.54±0.13 *	0.43±0.16 **
	Rmse1/mse2	1.18±1.18	0.68±0.01	0.64±0.06
	Rmse1/mse2(DN)	0.73±0.10	0.62±0.05 *	0.62±0.04 *
	R 1	0.88±0.03	0.88±0.05	0.86±0.08
	K trans	0.12±0.01	0.09±0.01 **	0.09±0.03 *
	v p	0.05±0.02	0.03±0.01 *	0.03±0.01 *
	v e	0.54±0.07	0.59±0.13	0.59±0.07
	k ep	0.22±0.04	0.16±0.03 **	0.15±0.04 **
Meningi-omas	Rmse1/mse2	1.00±0.08	4.91±38.2	0.85±0.04 **
	Rmse1/mse2(DN)	0.98±0.06	0.93±0.09	0.84±0.03 **

^aMSE, ΣMSE are in arbitrary unit, MSE_rel, ΣMSE_rel and R_mse1/mse2, k _ep are ratios. K ^trans is in minute⁻¹.

^bComparison of differences in DCE-MRI parameters between pre- and post-treatment in each group of tumors, i.e. VS (N = 7) and meningiomas (N = 5) for each pair of visits (Day 0 and day 3, day 0 and day 90).

*p<0.05,

**p<0.01.