Table 2. Stratified analyses of rs35399661, rs3763338 and rs2844695 by the clinical characteristics in ESCC.

	rs35399661				rs3763338				rs2844695
Clinical characteristics (n)	F_Ab	?2	P	OR (95%CI)	F_Ac	?2	P	OR (95%CI)	F_Ad	?2	P	OR (95%CI)
Sex
male (550)	0.12	2.970	0.085	0.79 (0.60–1.03)	0.09	0.109	0.082	0.95 (0.70–1.03)	0.38	0.001	0.978	0.68 (0.52–0.90)
female (387)	0.15				0.10				0.38
Age
>50 (847)	0.13	0.863	0.353	0.82 (0.53–1.25)	0.10	3.681	0.055	1.89 (0.98–3.64)	0.40	7.207	0.007	1.32 (1.07–1.62)
≤50 (90)	0.13				0.05				0.34
Family history
positive (284)	0.13	0.012	0.914	0.98 (0.74–1.32)	0.10	0.128	0.971	1.06 (0.76–1.48)	0.36	1.867	0.172	0.87 (0.71–1.06)
negative (645)	0.13				0.09				0.39
Drinking
drinkers (106)	0.11	1.295	0.255	0.77 (0.49–1.21)	0.11	0.367	0.262	1.16 (0.72–1.86)	0.42	1.673	0.196	1.22 (0.90–1.64)
nondrinkers (620)	0.14				0.10				0.38
Smoking
smokers (178)	0.13	0.148	0.701	0.93 (0.66–1.33)	0.11	0.499	0.719	1.15 (0.78–1.71)	0.41	1.571	0.210	1.17 (0.92–1.50)
nonsmokers (548)	0.14				0.09				0.38

^aMinor allele (A) frequency of rs17533090 in cases;

^bMinor allele (G) frequency of rs35399661 in cases;

^cMinor allele (A) frequency of rs3763338 in cases;

^dMinor allele (G) frequency of rs2844695 in cases; HIA: high-incidence area; LIA: low-incidence area. df = 1.