Table 2. Determinants of cervical intraepithelial neoplasia of any grade (n = 132) in 2,998 HIV-infected women in Abidjan, Côte d'Ivoire. The IeDEA West Africa collaboration.
| Univariate analysis | Final multivariate analysis | ||||||
| Variables | n/N | OR | 95% CI | P | OR | 95% CI | P |
| Age category (years) | 0.10 | 0.08 | |||||
| ≥25–34 | 46/1,211 | 1 | 1 | ||||
| ≥35–44 | 68/1,265 | 1.4 | 1.0–2.1 | 1.3 | 0.9–2.0 | ||
| ≥45–54 | 13/434 | 0.8 | 0.4–1.5 | 0.6 | 0.3–1.2 | ||
| ≥55–65 | 5/88 | 1.5 | 0.6–3.9 | 1.2 | 0.5–3.3 | ||
| Marital status | 0.02 | <10−2 | |||||
| Couple (married, cohabitant) | 46/1,344 | 1 | 1 | ||||
| Single (alone, divorced, widowed) | 86/1,654 | 1.5 | 1.1–2.2 | 1.6 | 1.1–2.4 | ||
| Parity | 0.01 | <10−2 | |||||
| No | 10/458 | 1 | 1 | ||||
| Yes (≥1) | 122/2,540 | 2.3 | 1.2–4.3 | 2.5 | 1.3–4.9 | ||
| Antiretroviral exposure (years)∫ | 0.05 | 0.26 | |||||
| Never | 26/731 | 1 | 1 | ||||
| ≥1 | 54/992 | 1.6 | 1.0–2.6 | 1.0 | 0.6–1.7 | ||
| ≥2–3 | 33/650 | 1.4 | 0.9–2.4 | 1.1 | 0.6–2.0 | ||
| ≥4 | 19/625 | 0.8 | 0.5–1.5 | 0.6 | 0.3–1.2 | ||
| Baseline CD4 count (cells/mm3)* | 0.02 | 0.50 | |||||
| ≤200 | 56/965 | 1 | 1 | ||||
| >200–350 | 37/768 | 0.8 | 0.5–1.2 | 1.0 | 0.6–1.6 | ||
| >350 | 36/1,181 | 0.5 | 0.3–0.8 | 0.7 | 0.5–1.2 | ||
| Unknown | 3/84 | 0.6 | 0.2–1.9 | 0.5 | 0.1–4.0 | ||
| Most recent CD4 count (cells/mm3)† | <10−4 | <10−3 | |||||
| ≤200 | 31/346 | 1 | 1 | ||||
| >200–350 | 36/621 | 0.6 | 0.4–0.9 | 0.6 | 0.4–1.0 | ||
| >350 | 62/1,957 | 0.3 | 0.2–0.5 | 0.3 | 0.2–0.6 | ||
| Unknown | 3/74 | 0.4 | 0.1–1.4 | 0.8 | 0.1–5.8 |
∫
Comparison of CD4 count (cells/mm3) according to ART duration (median [interquartile range]): ≥1 years: 358 [212–532], ≥2–3 years: 477 [313–650], ≥ 4 years 512 [366–691] (p<10−4).
*CD4 count (cells/mm3) measured during first clinical follow-up for HIV infection.
†
Last known CD4 count (cells/mm3) measured prior or during the cervical cancer screening visit.