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. 2014 Mar 4;9(3):e90608. doi: 10.1371/journal.pone.0090608

Figure 1. HBs proteins-induced liver injury depends on host genetic background.

Figure 1

(A) Assessment of liver damage in wild-type and HBV transgenic mice. ALT was measured in serum of 12-, 26-, and 52-week-old mice (mean±SEM, n = 5–10). (B-D) Western blot analysis of total protein lysates from the liver of 12-, 26-, and 52-week-old mice was performed using (B) anti-CHOP/GADD153, (C) anti-phospho-PERK, and (D) anti-phospho-eIF2α (Ser51) antibodies. Equal protein loading was confirmed with anti-PERK (B), anti-eIF2α (C), and anti-β-actin (D) antibodies. 1 – female BALB/c; 2,3 – female HBVTg/c; 4 – male BALB/c; 5, 6 – male HBVTg/c; 7 – female C57BL/6; 8, 9 – female HBVTg/6; 10 – male C57BL/6; 11, 12 – male HBVTg/6 mice.