Figure 4. Hepatic expression of lipogenic regulators in Zucker rats fed a high fat (HF) diet or the HF diet supplemented with 0.25% α-lipoic acid (HF-LA) for 30 days.

(A) Acetyl-CoA carboxylase (ACC) mRNA expression and protein abundance; (B) Fatty acid synthase mRNA expression and protein abundance (FAS); (C) cytoplasmic and nuclear sterol regulatory element binding protein 1c (SREBP1C) mRNA and protein. *, denotes a significant difference (p<0.05). All data normalized to β-actin and expressed relative to HF group; n = 8/group.