Figure 7.
mGluR1 stimulation selectively enhanced FS interneuron firing. A, Bath application of mGluR1 PAM Ro67–7476 increased evoked firing in FS interneurons of both control and CIE slices. B, Bath application of mGluR1 PAM Ro67–7476 decreased action potential duration in both controls and CIEs. C, mGluR1 PAMs Ro67–7476 and Ro71–1401 increased Kv3.1/3.2 currents in both control and CIE slices. D, Bath application of mGluR1 PAM decreased evoked firing of pyramidal neurons in both control and CIE slices and this effect was blocked by the GABAA blocker picrotoxin (PTX). *p < 0.05 versus baseline, paired t test, n = 4 cells from four rats.