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. 2014 Mar 5;5:43. doi: 10.3389/fgene.2014.00043

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Copyright © 2014 Amaral, Brito, Chobanyan, Yoshikawa, Yokokura, Van Vactor and Gama-Carvalho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative analysis of global and Smn expression profiles in Smn^X7/elavGAL4-C24 (X7/C24) and elavGAL4 (WT) flies. (A) Spatial distribution of global expression trends in WT and X7/C24. PCA was applied to the stabilized variances estimated from normalized reads counts of ~12,000 genes expressed in WT and X7/C24 samples. (B) Normalized reads counts of Smn gene in WT and X7/C24 phenotypes. The transgenic X7/C24 presents a transcriptome profile that clearly distinguishes it from the WT and displays a significant down-regulation of the siRNA target gene Smn.