Table 2.
Interaction of inflammatory caspases and cytosolic bacteria.
| Bacteria | Caspase-1 | Caspase-11 or -4 | ||
|---|---|---|---|---|
| Stimulus/sensor | NLRC4 | NLRP3 | AIM2 | |
| Burkholderia | BsaK/NAIP2 | Infection | LPS/casp11 | |
| Shigella | Needle/NAIP1 and human NAIP Rod/NAIP2 |
Infection | LPS/casp11 ?/casp4 | |
| Francisella | Infection (human) | DNA | ||
| Listeria | Flagellin/NAIP5 | Infection, LLO | DNA | |
| Rickettsia | ||||
| Mycobacterium | Infection, ESAT-6 | DNA | ||
| Antagonism | ||||
| Burkholderia | ||||
| Shigella | OspC3 inhibits casp4 | |||
| Francisella | possible | Tetra-acyl LPS | ||
| Listeria | Represses flagellin at host temperatures | pH dependent LLO activity | ||
| Rickettsia | ||||
| Mycobacterium | Zmp1 metalloprotease | |||