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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Curr Opin Microbiol. 2013 Dec 10;0:32–37. doi: 10.1016/j.mib.2013.11.004

Fig. 2.

Fig. 2

Neutrophil lysis after phagocytosis. Lysis after phagocytosis from within the neutrophil phagosome was demonstrated for S. aureus PSMα peptides and the leukotoxin LukAB (LukGH), illustrated here for PSMs. PSMs trigger neutrophil activation by interaction with the FPR2 receptor. After phagocytosis and phagosome formation, bacterial regulatory systems (Agr, stringent response) lead to PSM production and PSM-mediated phagosome lysis. Bacteria may further proliferate in the neutrophil. Upon ultimate neutrophil destruction the bacteria escape from the cell.