Table 2.
CRISPR and prophage content of GAS genomes.
| Strain(a) | Serotype | CRISPR(b) | Prophages in the genome(c) | Prophages targeted by CRISPR(d) | Ref. | |
|---|---|---|---|---|---|---|
| SF370 | M1 | 9 | 370.1 – 4 | 10270.1, 2 315.2, 3, 4, 5 SPsP2, 3, 4, 5 10750.1, 2, 3 10394.3, 4, 5 |
9429.2 8232.2, 3, 5 6180.2 NZ131.3 |
[61] |
| MGAS9429 | M12 | 9 | 9429.1 – 3 | 5005.1, 2 315.1, 2 SPsP5, 6 Man.1, 4 |
8232.1, 2,
5 6180.1 NZ131.3 |
[62] |
| NZ131 | M49 | 9 | NZ131.1 - 3 | 370.1,
3 5005.2 10270.3 315.3, 4 SPsP3, 4 10750.3 |
Man.1, 2 10394.4, 5, 6 2096.1 8232.2, 4, 5 6180.2 |
[63] |
| MGAS2096 | M12 | 8 | 2096.1 – 2 | 5005.1 315.1, 2 SPsP5 Man.1, 4 |
8232.1, 2,
5 6180.1 NZ131.3 |
[62] |
| MGAS5005 | M1 | 7 | 5005.1 – 3 | 370.1 10270.1, 2, 3 315.2, 4, 5 SPsP2, 4, 5 10750.1, 2 |
Man.1, 3,
4 10394.6 9429.1 8232.2, 5 NZ131.3 |
[64] |
| MGAS10270 | M2 | 6 | 10270.1 – 5 | 370.1 315.1, 2, 3 SPsP3, 4, 5 10750.3 |
Man.2, 3, 4 10394.3, 5 8232.1, 2, 3 6180.1 |
[62] |
| MGAS6180 | M28 | 5 | 6180.1 – 4 | 370.2, 3 5005.2 315.3, 5 SPsP2, 4, 5 |
10750.3 10394.4, 5 9424.2 8232.3, 4, 5 |
[65] |
| MGAS10750 | M4 | 5 | 10750.1 – 4 | 370.3 315.5 SPsP2 |
Man.1 8232.4 |
[62] |
| MGAS315 | M3 | - | 315.1 – 6 | - | [66] | |
| SSI-1 | M3 | - | SPsP1 – 6 | - | [67] | |
| Manfredo | M5 | - | Man.1 – 5 | - | [68] | |
| MGAS10394 | M6 | - | 10394-1 – 8 | - | [69] | |
| MGAS8232 | M18 | - | 8232.1 – 5 | - | [70] | |
(a)
Strains are ordered from highest to lowest total number of CRISPR spacers.
(b)
Number of spacers is indicated.
(c)
Prophages and prophage remnants are indicated.
(d)
Prophages carry the name of the host strain followed by a serial number. Note that there is a mutually exclusive relationship between CRISPR-Cas systems and prophage content. For example, the CRISPR spacers present in strain SF370 match prophages present in other strains, but none of the 370.1-4 endogenous prophages.