Table 2.

Distribution of NNRTI Resistance Mutations,^a LEGACY Cohort, United States, 2001–2006

	Did not recycle NNRTI-based regimen N=117 n (%)	Recycled NNRTI-based regimen N=16 n (%)	p Value
Major NNRTI mutations
L100I	9 (7.7)	0 (0)	0.60
K101E	10 (8.6)	5 (31.3)	0.02
K103N	72 (61.5)	3 (18.8)	<0.01
V106A	3 (2.6)	0 (0)	1.00
V106M	1 (0.9)	0 (0)	1.00
V108I	15 (12.8)	3 (18.8)	0.45
Y181C	30 (25.6)	8 (50.0)	0.07
Y181I	0 (0)	1 (6.3)	0.12
Y188C	3 (2.6)	0 (0)	1.00
188H	3 (2.6)	1 (6.3)	0.40
Y188L	10 (8.6)	1 (6.3)	1.00
G190A	16 (13.7)	5 (31.3)	(0.13)
P225H	10 (8.6)	0 (0)	0.61
Minor NNRTI mutations
K103S	1 (0.9)	0 (0)	1.00
V179D	6 (5.1)	0 (0)	1.00
V179E	1 (0.9)	0 (0)	1.00
G190E	1 (0.9)	0 (0)	1.00
G190S	3 (2.6)	1 (6.3)	0.40
G190A/E	16 (13.7)	5 (31.3)	0.13

^aResistance mutations not mutually exclusive.