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The schematic depiction of FUS-mediated MnSOD gene transcription. FUS binds to a FUS binding element identified in the upstream MnSOD promoter and interacts with transcription factor Sp1 and nucleophosmin. This interaction leads to activation of MnSOD gene transcription. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
